Morroniside Inhibiting Ca2+ after Platelet Aggregation Induced by Adenosine Diphosphate in Rabbits

VernacularTitle:莫诺苷对二磷酸腺苷诱导兔血小板聚集钙离子的影响
Author: Houxi AI ; Wei ZUO ; Xiaofeng WANG ; Li ZHANG ; Hui JI ; Naihong CHEN ; Wen WANG
Publication Type:Journal Article
Keywords: morroniside, platelet aggregation, calcium, rabbits
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(2):131-133
CountryChina
Language:Chinese
Abstract: Objective To explore the effects of morroniside on Ca2++ in the condition of platelet aggregation in rabbits induced by adenosine diphosphate (ADP). Methods The mobilization of cytosolic-free calcium after platelet aggregation induced by ADP was detected by Ca2++-sensitive fluorescent indicator, Fura-2 AM and time scan measurement. Results Compared with the controls, morroniside significantly inhibited the increase of Ca2++ induced by ADP (P<0.001). Conclusion Morroniside acts as an effective platelet aggregative antagonist by inhibiting the increase of platelet Ca2++.