Extraregional lymph node recurrence of stage IA1 squamous cell carcinoma of the uterine cervix after initial surgery: two case studies

Kana Sekigawa; Hidenori Umeki; Aya Osonoi; Mikiko Tsugata; Ichiro Ono; Eisaku Ito; Keijiro Sumori

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Extraregional lymph node recurrence of stage IA1 squamous cell carcinoma of the uterine cervix after initial surgery: two case studies

VernacularTitle:Extraregional lymph node recurrence of stage IA1 squamous cell carcinoma of the uterine cervix after initial surgery: two case studies
Author: Kana SEKIGAWA ¹ ; Hidenori UMEKI ¹ ; Aya OSONOI ² ; Mikiko TSUGATA ¹ ; Ichiro ONO ³ ; Eisaku ITO ⁴ ; Keijiro SUMORI ³
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1. Department of Obstetrics and Gynecology, JA Toride Medical Center, Japan
2. Department of Obstetrics and Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Japan
3. Department of Obstetrics and Gynecology, Ome Municipal General Hospital, Japan
4. Department of Pathology, Ome Municipal General Hospital, Japan
Keywords: cervical cancer; lymph node recurrence; stage IA1; serum squamous cell carcinoma (SCC) antigen; in situ hybridization
From:Journal of Rural Medicine 2022;17(4):255-258
CountryJapan
Language:English
Abstract: Objective: Lymph node recurrence is extremely rare in cases of stage IA1 squamous cell carcinoma (SCC) of the uterine cervix without lymphovascular space invasion (LVSI). We present two cases of extraregional lymph node recurrence after initial surgery for stage IA1 SCC of the uterine cervix without LVSI.Patients: Both patients initially underwent hysterectomy and developed recurrent extraregional lymph nodes within a few years postoperatively.Case 1: The patient showed no symptoms of recurrence, and follow-up computed tomography (CT) for evaluation of gallstones revealed a para-aortic lymph node (9 mm). The patient subsequently underwent serum SCC antigen testing and CT and was diagnosed with recurrence.Case 2: The patient noticed a right inguinal node swelling, which was evaluated using CT. Both patients survived without relapse for 8 and 4 years, respectively.Conclusion: Although stage IA1 SCC of the uterine cervix without LVSI is associated with a low risk of lymph node recurrence, oncologists should consider the possibility of recurrence in such cases. Evaluation for recurrence is difficult in asymptomatic patients. Serum SCC antigen testing may be a useful biochemical marker before imaging for early detection of recurrence, even in asymptomatic patients.