Effect and Mechanism of Traditional Chinese Medicine in Treatment of Ulcerative Colitis： A Review
10.13422/j.cnki.syfjx.20222339
- VernacularTitle:中药治疗溃疡性结肠炎作用及机制研究进展
- Author:
Chunxia WANG
1
;
Junli GE
1
;
Fang LI
1
;
Kunpeng ZHAO
2
;
Shijun SHAO
3
;
Fude YANG
1
;
Jinliang FENG
4
Author Information
1. College of Pharmacy，Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Clinical College of Chinese Medicine，Gansu University of Chinese Medicine，Lanzhou 730000，China
3. Lanzhou Institute of Chemical Physics，Chinese Academy of Sciences，Lanzhou 730000，China
4. Gansu Kangle Pharmaceutical Co. Ltd.，Lanzhou 730300，China
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
active ingredients of traditional Chinese medicine（TCM）;
TCM extracts;
TCM pairs;
classic TCM compounds;
combined use of TCM with chemical agents;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):270-282
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC） is a chronic non-specific digestive disease with abdominal pain， diarrhea， and blood and mucus in stool as the main clinical manifestations and inflammatory injury of colorectal mucosa and submucosa as the main pathological changes. With the change in living habits and dietary structure of people， the incidence and cancer morbidity in UC are rising rapidly all over the world， which has seriously reduced the quality of life and caused a huge social burden. Till now， the pathogenesis has not been elucidated. In western medicine， aminosalicylates， corticosteroids， and immunosuppressors are commonly used to relieve symptoms. However， the long-term application will lead to problems such as decreased efficacy and increased adverse reactions. There are more studies of traditional Chinese medicine （TCM） in the treatment of UC by reducing the inflammatory response， alleviating oxidative stress， protecting the intestinal mucosal barrier， and regulating intestinal microecological imbalance by virtue of the advantages of integrated regulation based on multiple links， levels， and targets. In view of this， the present study reviewed the effect and mechanism of active ingredients of TCM， TCM extracts， TCM pairs， classic TCM compounds， and TCM combined with chemical agents in the treatment of UC based on relevant research articles in recent 10 years to provide references for seeking effective drugs.
