Effect of Intestinal Tight Junction in Diarrhea-predominant Irritable Bowel Syndrome and Traditional Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20222493
- VernacularTitle:肠紧密连接在腹泻型肠易激综合征中的作用及中医药干预的研究进展
- Author:
Jinxin WANG
1
;
Sheng XIE
2
;
Maoguang HUANG
1
;
Feng LUO
1
;
Yueying CHEN
1
;
Yuling LI
1
;
Liqun LI
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine，Nanning 530001， China
2. The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530001，China
- Publication Type:Journal Article
- Keywords:
diarrhea-predominant irritable bowel syndrome （IBS-D）;
tight junction;
traditional Chinese medicine;
action mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):253-259
- CountryChina
- Language:Chinese
-
Abstract:
Diarrhea-predominant irritable bowel syndrome （IBS-D） is a chronic intestinal disease characterized by abdominal pain and increased water content in stool. The pathological mechanism of this disease is complex and attributed to many factors， where the impairment of intestinal mucosal barrier is pivotal in the pathogenesis of IBS-D. The intercellular tight junction （TJ）in intestinal mucosa is mainly composed of Occludin，Claudins， and zonula occludens （ZOs），which is an important component of mechanical barrier and can significantly affect mucosal function. Since modern medicine holds that the pathogenesis of this disease is not fully revealed，symptomatic treatment is the first choice in clinical practice even though the outcomes are not satisfactory. According to traditional Chinese medicine （TCM），the epithelial barrier function in intestinal mucosa corresponds to the TCM theory of "the spleen acts as the guard". Many studies have reported that the active components of Chinese medicine and compound prescriptions can restore the intestinal epithelial barrier function of IBS-D rats by regulating TJ protein，reduce its permeability， and inhibit intestinal water and electrolyte exudation，thereby improving symptoms. This study reviewed the relationship of IBS-D with TJ and its key target proteins to clarify the key role of TJ in the pathophysiology of IBS-D and summarized the TCM treatment of IBS-D through the target regulation of TJ， with the purpose to provide a theoretical basis for the treatment of IBS-D and further drug development.
