Mechanism of Tumor Suppressor miRNAs in Migration and Invasion of Nasopharyngeal Carcinoma and Intervention of Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20221727
- VernacularTitle:抑癌微小RNAs在鼻咽癌迁移和侵袭中的作用机制及中医药干预作用
- Author:
Jie LIU
1
;
Jingying FAN
1
;
Lan HE
1
;
Bo CHENG
1
;
Yingchun HE
1
Author Information
1. Hunan University of Chinese Medicine， Changsha 410208， China
- Publication Type:Journal Article
- Keywords:
tumor suppressor micro-ribonucleic acid （miRNAs）;
nasopharyngeal carcinoma;
migration;
invasion;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):235-243
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma （NPC）， characterized by insidious onset and non-specific features at the initial stage， is usually diagnosed at middle or late stage with metastasis. The invasion and metastasis of NPC involve complex biological processes， which are affected by many factors. The regulation of gene expression is involved in the invasion and metastasis of NPC， which has become a hot topic. Micro-ribonucleic acids （miRNAs） are short （about 22 nucleotides long） non-coding ribonucleic acids （RNAs） that participate in each step of invasion and metastasis of malignant tumor cells and play an important regulatory role by modulating the transcription and translation of target genes. Abnormal expression of miRNAs has been found in NPC， which regulates the invasion and metastasis of NPC cells. This paper summarized the regulatory mechanisms of different miRNAs as tumor suppressor genes in the migration and invasion of NPC cells， including the modulation of target genes， migration-and invasion-related proteins， and important signaling pathways， which involve biological processes such as epithelial-mesenchymal transition （EMT）， neovascularization and lymphatic vessels， tumor stem cells， and resistance to radiotherapy and chemotherapy. As Chinese medicine shows remarkable efficacy in the prevention and control of NPC， especially in the alleviation of adverse reactions and reduction of metastasis rate after radiotherapy and chemotherapy， we also summed up the effect and mechanism of Chinese medicine and the active components in inhibiting the migration and invasion of NPC cells by miRNAs. Thereby， this review is expected to lay a theoretical basis for further research and development of new drugs against NPC.
