Anti-tumor Effect of Chinese Medicine by Inducing Cell Cycle Arrest： A Review
10.13422/j.cnki.syfjx.202201821
- VernacularTitle:中药诱导细胞周期阻滞抗肿瘤研究进展
- Author:
Yaxin LIU
1
;
Xuejiao WEI
1
;
Huiming HUANG
1
;
Lishan OUYANG
1
;
Jinxin XIE
1
;
Longyan WANG
1
;
Dongxiao LIU
1
;
Pengfei TU
1
;
Zhongdong HU
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine， School of Chinese Materia Medica， Beijing University of Chinese Medicine， Beijing 100029， China
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
anti-tumor;
cell cycle;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):222-234
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence and mortality of cancer have been on the rise， and it has been the global leading cause of death. The causes of cancer are diverse， such as heredity， radiation， and carcinogens. The abnormality of cell cycle regulation is also one of the causes. Cell cycle is a complex sequence of events through which a cell duplicates its contents and divides. Cell cycle is highly organized to ensure the integrity of genetic material. This process involves many regulatory genes and proteins. Cell cycle will be dysregulated when these proteins and genes change， resulting in the loss of control of cell proliferation， the inhibition of apoptosis， and finally the occurrence of tumor. At the moment， the therapies for cancer include traditional surgical resection， radiotherapy， chemical therapy， and targeted therapy. Chinese medicine has a wide range of sources and little side effect， which is worthy of further research and development. More and more studies have revealed that a variety of Chinese medicines play an anti-tumor role by inducing cell cycle arrest， so as to improve the quality of life and prolong the survival time of patients with advanced tumors. This article first introduces the characteristics and related regulatory factors of each phase of cell cycle， and enumerates the clinical and experimental examples of tumorigenesis caused by abnormal cell cycle. Then， we summarize the hot anti-tumor drugs targeting cell cycle in China and abroad， such as Cyclin-dependent kinase （CDK） inhibitors， cell division cycle 25 （CDC25） inhibitors， ataxia-telangiectasia-mutated-and-Rad3-related kinase （ATR） inhibitors， and checkpoint kinase 1 （CHK1） inhibitors. Finally， this article summarizes the recent research on the anti-tumor effect of Chinese medicine by inducing cell cycle arrest from the three aspects of cell cycle G0/G1 phase， S phase and G2/M phase， in order to provide some reference for the research on the anti-tumor effect of Chinese medicine.
