Relationship Between Pathogenesis of "Kidney Deficiency and Blood Stasis in Collateral， Miniature Mass of Renal Collateral" and Autophagy Dysfunction in Renal Interstitial Fibrosis
10.13422/j.cnki.syfjx.20221526
- VernacularTitle:“肾虚络瘀，肾络癥瘕”病机观与肾间质纤维化中自噬不足的相关性
- Author:
Jiansheng LI
1
;
Yingming WANG
2
;
Yanshun YAN
2
;
Jianlin CHENG
1
;
Wennian ZHANG
2
;
Guilan KANG
2
Author Information
1. Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730050， China
2. Gansu University of Chinese Medicine， Lanzhou 730030， China
- Publication Type:Journal Article
- Keywords:
renal interstitial fibrosis;
autophagy dysfunction;
kidney deficiency and blood stasis in collateral;
miniature mass of renal collateral
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):186-194
- CountryChina
- Language:Chinese
-
Abstract:
Renal interstitial fibrosis （RIF） is the main pathological feature of chronic kidney disease caused by a variety of factors. "Kidney deficiency and blood stasis in collateral， miniature mass of renal collateral" is the main pathogenesis of RIF. The deficiency of healthy Qi will influence the kidney Qi， resulting in kidney deficiency and unsmooth qi transformation. As a result， phlegm， heat， stasis， toxin and other excess pathogens block the kidney collaterals， forming miniature masses. The masses accumulate in the renal collaterals， finally leading to RIF. Autophagy is a key process that keeps your body's cells in proper balance by taking aged or damaged components in a cell and recycling them. It is involved in the occurrence and development of RIF. The metabolism of excess pathogens such as phlegm， heat， stasis， and toxin in vivo is related to the degradation and reabsorption of autophagy. Autophagy is a way to eliminate phlegm， heat， stasis， toxin and other excess pathogens. Autophagy dysfunction will cause the accumulation of phlegm， heat， blood stasis， toxin and other excess pathogens， further the stasis of the kidney collaterals， miniature mass in kidney， and finally RIF. Kidney deficiency and blood stasis in collateral are the root cause of autophagy dysfunction， and the miniature mass of renal collateral is the manifestation of autophagy dysfunction. Autophagy dysfunction and miniature mass of renal collateral have the same pathological evolution. In this paper， based on the pathogenesis of "kidney deficiency and blood stasis in collateral， miniature mass of renal collateral" of RIF and RIF-autophagy relationship， this paper discusses the "kidney deficiency and blood stasis in collateral-autophagy dysfunction-miniature mass of renal collateral" relationship in RIF and comprehensively interprets the scientific connotation of the pathogenesis of "kidney deficiency and blood stasis in collateral， miniature mass of renal collateral"， which is expected to lay a basis for explaining the role of autophagy in TCM theory and for the treatment of RIF and research on the mechanism.
