Application of Animal Models of Type 2 Diabetes Mellitus： Based on Data Mining
10.13422/j.cnki.syfjx.20221511
- VernacularTitle:基于数据挖掘的2型糖尿病动物模型应用分析
- Author:
Xiangning HUANG
1
;
Xinyi YAO
1
;
Yan TAN
2
;
Rong YU
2
Author Information
1. The First Hospital of Hunan University of Chinese Medicine， Changsha 410007， China
2. Hunan University of Chinese Medicine， Changsha 410208， China
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
animal models;
data mining;
modeling elements;
detection indexes
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):159-165
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the modeling elements and detection indexes of type 2 diabetes mellitus （T2DM） animal models， to provide a reference for establishing animal models with related pathogenesis in a cost-effective and simple manner， and to lay a basis for the research on relevant pathogenesis and pharmacological mechanism. MethodPapers on animal experiment of T2DM which were published from January 1， 2011 to December 31， 2021 were retrieved from China Knowledge Network， Wanfang Data， and PubMed. Data on the types and genders of animals， modeling methods， and evaluation indexes and methods were collected used to establish a database. Then， Excel and SPSS 18.0 were employed for data analysis. ResultA total of 249 eligible papers were included and male SD rats were mainly used for the modeling. The combination of chemical and diet was mainly adopted for the modeling， with streptozotocin （STZ） as the main chemical and high-fat and high-sugar diet as the main diet. The evaluation indexes of serum biochemical indexes， histopathology， and related indexes were frequently used. ConclusionIn animal experiment on T2DM， male SD rats are mainly adopted for modeling. The frequently used modeling method is the combination of high-fat and high-sugar diet （containing 10% lard and 20% sucrose） or high-fat diet （containing 40%-60% fat） with small dose of STZ （30-40 mg·kg-1， intraperitoneal injection， once）. This method is characterized by ease of implementation and high success rate， and the yielded animal model has the disease pathogenesis. The models are often evaluated based on blood glucose， blood lipid profile， serum insulin， glucose tolerance test or insulin tolerance test. The findings are expected to serve as a reference for research on basic animal experiment on T2DM.
