Clinical Efficacy of Xiaoyaosan Combined with Paroxetine Tablets in Treatment of Migraine with Liver Depression and Blood Deficiency Syndrome and Depression Based on Transcranial Doppler
10.13422/j.cnki.syfjx.20230195
- VernacularTitle:基于TCD探讨逍遥散联合帕罗西汀片治疗肝郁血虚型偏头痛与抑郁共病的临床疗效
- Author:
Meng ZHANG
1
;
Meixia WANG
1
;
Qian ZHAO
1
;
Yu ZHANG
1
;
Yimin CHEN
1
;
Yanyun ZHANG
1
Author Information
1. The First Afffiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China
- Publication Type:Journal Article
- Keywords:
migraine;
depression;
transcranial Doppler（TCD）;
Xiaoyaosan;
paroxetine tablets
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(2):113-118
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveBased on the hemodynamic indicators of transcranial Doppler （TCD），this study aimed to analyze the correlations of visual analogue scale（VAS） and Hamilton depression rating scale 24-item（HAMD-24） scores with mean blood velocity （Vm） of the anterior cerebral artery （ACA），the middle cerebral artery （MCA）， and the posterior cerebral artery （PCA），and the correlation between VAS score of headache and HAMD-24 score，and explore the clinical efficacy of Xiaoyaosan combined with paroxetine tablets in the treatment of migraine with liver depression and blood deficiency syndrome and depression. MethodSixty-two outpatients treated in the encephalopathy department， the First Afffiliated Hospital of Anhui University of Chinese Medicine between January 2019 to June 2020 who were in line with the diagnostic criteria were enrolled and divided into a treatment group （32 cases） and a control group （30 cases）. All patients were treated with paroxetine tablets，while those in the treatment group received additional Xiaoyaosan. The changes in relevant indicators in the two groups before and after treatment were observed. The effects of Xiaoyaosan on the TCD indicators （VmACA， VmMCA， and VmPCA）， scores of migraine and depression ［including VAS score， Headache Impact Test-6 （HIT-6） score，and HAMD-24 score］， and the traditional Chinese medicine （TCM） syndrome score were analyzed. ResultVAS and HAMD-24 scores were positively correlated with VmACA， VmMCA， and VmPCA （P<0.01）. VAS scores were positively correlated with HAMD-24 scores. Compared with the conditions before treatment， the levels of TCD indicators （VmACA， VmMCA， and VmPCA） in the two groups decreased after treatment （P<0.01）， and the scores of HIT-6， VAS， and HAMD-24 in the two groups were significantly improved （P<0.01）. Compared with the control group after treatment， the treatment group showed decreased levels of TCD indicators （VmACA， VmMCA， and VmPCA） （P<0.01） and superior improvement of HIT-6， VAS， and HAMD-24 scores （P<0.01）. The effective rate in the treatment group was 90.6% （29/32）， higher than 63.3% （19/30） in the control group （χ2=5.13，P<0.05）. There was no significant difference in adverse reactions between the two groups. ConclusionTCD indicators can effectively reflect the cerebral blood flow of patients with migraine and depression co-morbidity，and migraine is correlated with the onset and severity of depression. The comprehensive analysis showed that the efficacy of Xiaoyaosan combine paroxetine tablets was better than that of paroxetine tablets alone in the treatment of migraine with liver depression and blood deficiency syndrome and depression. This therapeutic protocol can significantly improve cerebral blood flow and the symptoms and degree of migraine and depression and can provide references for clinical treatment.
