Effects of Acupuncture on Blood Lipids in Hyperlipidemia Mice
10.3969/j.issn.1006-9771.2013.12.007
- VernacularTitle:针刺对高脂血症小鼠血脂的影响及其机制研究
- Author:
Jia GUO
;
Xiaolan JI
;
Bo PENG
;
Fuyun LI
;
Li ZHANG
;
Cheng LIU
;
Zejun HUO
- Publication Type:Journal Article
- Keywords:
hyperlipidemia, acupuncture, angiotensin II, endothelin-1, receptor, mice
- From:
Chinese Journal of Rehabilitation Theory and Practice
2013;19(12):1120-1123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of acupuncture on blood lipids of hyperlipidemia mice, and explore the mechanism of acupuncture against endothelial dysfunction. Methods 40 ApoE (-/- ) mice were randomly divided into control group (C), acupuncture at non-acupoint group (D), acupuncture at acupoint group (E), and simvastatin group (F) with 10 cases in each group. After 8 weeks, total cholesterol (TC), the plasma angiotensin II (Ang II), endothelin-1 (ET-1) and nitric oxide (NO) were measured with enzyme-linked immuno sorbent assay (ELISA). The mice myocardial angiotensin II type 1 receptor (AT1R), and endothelin-1 type A receptor (ETAR) protein were detected with Western blotting. Results The blood lipid, the content of plasma Ang II and ET-1, and the level of AT1R and ETAR in the heart tissue were significantly lower, and the content of NO was significantly higher in groups E and F than in group C (P<0.05). Conclusion Acupuncture can inhibit the level of blood lipids in ApoE(-/-) mice, reduce the levels of Ang II and ET-1, increase the level of NO in peripheral blood, and inhibit the expression of AT1R, ETAR in heart tissue.
