Efficacy and Safety of Solifenacin in Neurogenic Detrusor Overactivity
10.3969/j.issn.1006-9771.2013.12.004
- VernacularTitle:索利那新对神经源性逼尿肌过度活动的效果观察
- Author:
Guoqing CHEN
;
Limin LIAO
;
Juan WU
;
Yu TIAN
- Publication Type:Journal Article
- Keywords:
neurogenic detrusor overactivity, solifenacin, efficacy, safety
- From:
Chinese Journal of Rehabilitation Theory and Practice
2013;19(12):1111-1113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of solifenacin in patients with neurogenic detrusor overactivity (NDO). Methods 50 patients with NDO received solifenacin 5 mg/d. During the treatment period, the voiding diary, Patient Perception of Bladder Condition-Scale (PPBC-S) and side effects were recorded. Results 2 weeks and 12 weeks later, the volume of the catheterization every time increased from (224.2±15.7) ml at baseline to (302.6±23.3) ml and (301.3±21.1) ml (P<0.05); the volume of leakage every day decreased from (753.9±121.7) ml to (444.1±87.1) ml and (449.1±89.2) ml (P<0.05); PPBC-S score decreased from (5.12±0.072) to (4.36±0.073) and (4.36±0.068) (P<0.05). There were 3 cases (6%) with dry mouth, and no patients complained dry eyes and blurred vision. Conclusion Solifenacin is safe and effective, and can significantly improve the quality of life in patients with NDO.
