Effects of Low Intensity Treadmill Training on Spatial Learning and Memory and Expression of Glycogen Synthase Kinase-3β in Hippocampus in Mice
10.3969/j.issn.1006-9771.2013.11.005
- VernacularTitle:小强度跑台运动对小鼠空间学习记忆及海马糖原合成酶激酶-3β的影响
- Author:
Huili LIU
;
Gang ZHAO
- Publication Type:Journal Article
- Keywords:
treadmill exercise, spatial learning and memory, glycogen synthase kinase-3β, mice
- From:
Chinese Journal of Rehabilitation Theory and Practice
2013;19(11):1016-1019
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of low intensity treadmill training on spatial learning and memory and expression of glycogen synthase kinase-3β (GSK-3β) in hippocampus in mice. Methods 24 female C57BL/6J mice of 3 months were assigned into control group (n=12) and exercise group (n=12). They were assessed with Morris Water Maze task 5 months after exercise. The GSK-3β protein and mRNA expressed in hippocampus were determined 1 week after the task. Results The latency and path length to escape onto the hidden platform decreased in the exercise group (P<0.05), while the cross times increased (P<0.05) compared with the control group. The level of GSK-3β mRNA decreased (P<0.05) and ratio of p-GSK-3β-Ser9 to GSK-3β increased (P<0.05) as well. Conclusion Low intensity treadmill exercise may improve the spatial learning and memory in mice, which may down-regulate the expression and activity of GSK-3β.