Major mechanisms of hepatitis B virus induced hepatocarcinogenesis
10.19428/j.cnki.sjpm.2022.22062
- VernacularTitle:乙肝病毒致癌主要机制
- Author:
Pei ZHAO
1
;
Yifan CHEN
2
;
Wenbin LIU
2
;
Letian FANG
2
;
Hongping YU
1
;
Guangwen CAO
2
Author Information
1. Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, China
2. Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China
- Publication Type:Review
- Keywords:
hepatitis B virus;
hepatocellular carcinoma;
mutation;
inflammation;
viral mutation
- From:
Shanghai Journal of Preventive Medicine
2022;34(10):1058-1064
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of hepatocellular carcinoma （HCC） induced by chronic infection of hepatitis B virus （HBV） is a typical process of Cancer Evolution-development. Viral replication， viral mutation， and viral integration are three major mechanisms by which HBV promotes evolution of HCC. The replication of HBV induces and maintains chronic inflammatory microenvironment， that induces the generation of somatic mutation and viral mutation and provides selective pressure. HBV mutation helps cells to get stem-ness characteristics by activating key signaling pathways. HBV integration activates oncogenes， participates in the mechanism underlying the male predilection of HCC， and promotes the maintenance of chronic infection. Biomarkers related with HBV are effective predictive and prognostic markers of HCC. Anti-viral treatment significantly reduces the risk of HCC occurrence. High risk HBV mutations can be applied for predicting the effect of anti-viral treatment on improving HCC survival. Continuing to exploring mechanisms of HBV induced hepatocarcinogenesis can improve the specific prophylaxis of HCC by providing more effective biomarkers and therapeutic targets.
