Relationship between Gene Polymorphism of Factor VII R353Q and Cerebral Palsy for Han Chinese Children
10.3969/j.issn.1006-9771.2013.09.023
- VernacularTitle:凝血因子ⅦR353Q基因多态性与中国汉族儿童脑性瘫痪的相关性研究
- Author:
Xiaojie LI
;
Lei XU
;
Beibei KANG
- Publication Type:Journal Article
- Keywords:
cerebral palsy, Han, factor VII R353Q, gene polymorphism
- From:
Chinese Journal of Rehabilitation Theory and Practice
2013;19(9):878-880
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between gene polymorphism of factor VII R353Q (FVII R353Q) and cerebral palsy for Han Chinese children. Methods Polymerase chain reaction-restricted fragment length polymorphism were used to determine genotype and allele of R353Q gene in 160 children with cerebral palsy and 137 normal children. Results The genotype of FVII R353Q is close to Hardy-Weinberg equilibrium in both CP group and control group (P>0.05). There was not significant difference in the distribution of the allelic frequency and genotype of FVII R353Q between the both groups (P=0.436, P=0.182, respectively). Conclusion The gene polymorphism of FVII R353Q is not significantly related with cerebral palsy for Han Chinese children.
