Effects of Monocyte Chemoattractant Protein-1 on Migration of Endogenous Neural Stem Cells
10.3969/j.issn.1006-9771.2013.09.006
- VernacularTitle:单核细胞趋化蛋白-1 在内源性神经干细胞迁移中的作用
- Author:
Peng DING
;
Changsheng ZHOU
;
Xiaosen DAI
;
Bin LU
;
Chongqian WANG
;
Weimin WANG
;
Jinkun WANG
- Publication Type:Journal Article
- Keywords:
cerebral injury, neural stem cells, monocyte chemoattractant protein-1, migration, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2013;19(9):820-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of monocyte chemoattractant protein-1 (MCP-1) on the migration of neural stem cells in vivo. Methods The brain injured rat model was established with cortical micro-injection of lipopolysaccharide in Sprague-Dawley rats. The tissue of brain was immunohistochemistrically stained to detect the expression of MCP-1 and nestin 3 d, 5 d, and 7 d after modeling. Results The expression of MCP-1 increased, and reached a peak 5 d after modeling. The nestin-positive cells was found in the lipopolysaccharide injected area 7 d after modeling. Conclusion MCP-1 may induce the endogenous neural stem cells migrate to lipopolysaccharide injection area in vivo.
