Prognostic Factors in Transcatheter Arterial Chemoembolizationc of Hepatocellular Carcinoma: Analysis of Morethan 3 Year Survivors.
10.3348/jkrs.1999.40.6.1113
- Author:
Heung Suk SEO
1
Author Information
1. Department of Diagnostic Radiology, Hanyang University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Liver neoplasms, chemotherapeutic infusion;
Arteries, therapeutic blockade;
Hepatic arteries, chemotherapeuticinfusion
- MeSH:
Carcinoma, Hepatocellular*;
Child;
Ethiodized Oil;
Gelatin Sponge, Absorbable;
Humans;
Liver;
Portal Vein;
Survivors*
- From:Journal of the Korean Radiological Society
1999;40(6):1113-1117
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine which prognostic factors contribute to long-term survival after transcatheter arterialchemoembolization(TACE) of hepatocellular carcinoma. MATERIALS AND METHODS: In 100 patients who expired withinone year and 84 who survived or have survived for more than 3 years after TACE, prognostic factors wereretrospectively evaluated. TACE was accomplished by hepatic arterial infusion of a suspension of Lipiodol andanticancer drugs(Mitomycin-C and Adriamycin), either alone or followed by gelfoam embolization. Fisher 's exacttest of probability was used to determine which prognostic factors were statistically significant. RESULTS:Statistically significant prognostic factors were as follows: Child classification(p<0.01), alpha-fetopro-teinvalue(p<0.05), type of tumor(p<0.01), portal vein status(p<0.01), and vascularity of the tumor(p<0.05). HBsAg,tumor size, and method of chemoembolization were not statistically significant(p>0.05). CONCLUSION: The prognosisof patients with hepatocellular carcinoma treated by TACE was affected favorably by good liver function(Childclassification A), low alphafetoprotein value, nodular or massive-type tumor, patent main and first-order portalvein, and hypervascular tumor.
