Effect of Ganglioside Combined with Hyperbaric Oxygen on Spastic Cerebral Palsy

VernacularTitle:神经节苷酯联合高压氧治疗小儿痉挛型脑瘫
Author: Zhi LIN ; Hui CHEN ; Honggang LI ; Fang YANG
Publication Type:Journal Article
Keywords: spastic cerebral palsy, ganglioside, hyperbaric oxygen, infants
From: Chinese Journal of Rehabilitation Theory and Practice 2013;19(3):255-256
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of combination of ganglioside and hyperbaric oxygen on spastic cerebral palsy. Methods 128 infants with spastic cerebral palsy were divided into treatment group (n=70) and control group (n=58), who received ganglioside and hyperbaric oxygen or cytidine diphosphate choline. The infants in the treatment group were divided into young group (6～12 months, n=38) and old group (1～3 years, n=32) according to their age. They were assessed with Ashworth scale and Functional Independence Measure (FIM) before and 3 courses after treatment. Results The scores of Ashworth scale and FIM improved more in the treatment group than in the control group (P<0.01) after treatment, as well as in the young group than in the old group (P<0.01). Conclusion The combination of ganglioside and hyperbaric oxygen is effective on spasticity and activities of daily living in infants with spastic cerebral palsy. The younger the infants are, the more effective it is.