Relationship between Expression of Peroxisome Proliferators-activated Receptors γ in Gliomas and Outcome of Patients

VernacularTitle:胶质瘤中过氧化物酶体增殖物激活受体γ表达与预后的关系
Author: Changsheng ZHOU ; Jinkun WANG ; Weimin WANG ; Chouqian WANG ; Yajun SHANG ; Bo WANG ; Linjie MOU ; Hao ZHANG ; Wen SU ; Peng DING
Publication Type:Journal Article
Keywords: glioma, peroxisome proliferators-activated receptors γ, immunohistochemistry, outcome
From: Chinese Journal of Rehabilitation Theory and Practice 2013;19(3):235-238
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship among expression of peroxisome proliferators-activated receptors γ (PPARγ) in human glioma, malignancy and outcome. Methods The level of PPARγ was detected with immunohistochemistry in the glioma from 48 cases with glioma. The progression-free survival and overall survival were compared with Kaplan-Meier survival curve between the patients with more expression of PPARγ and less ones. Results The expression of PPARγ decreased (P<0.01) with the the tumor malignancy increasing from grade I to IV, which was negatively correlated (r=-0.770, P<0.01). Both the progression-free and overall survival time were significant difference between the patients with more expression of PPARγ and less ones (P<0.01). Conclusion PPARγ expression correlates with the malignancy of human glioma, which may predict the outcome of the patients.