Syndrome Differentiation and Treatment of Psoriasis by Regulating Classical JAK/STAT Signaling Pathway with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20230299
- VernacularTitle:中医药调控JAK/STAT经典信号通路辨治银屑病的研究进展
- Author:
Dongdong WU
1
;
Xun CAO
2
;
Yuepeng AN
1
Author Information
1. The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
Janus kinase （JAK）;
signal transducer and activator of transcription factor （STAT）;
psoriasis;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(1):258-269
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of psoriasis is very complex，involving multiple genes，cells， and factors. These factors signal layer by layer through a series of cascade reactions，thus forming many biological pathways of disease occurrence. The study of the psoriasis-related signaling pathway has become the core way of disease mechanism exploration and drug intervention. Among all the signaling pathways related to psoriasis，Janus kinase （JAK）/signal transducer and activator of transcription protein （STAT） signaling pathway is the top classic one. The JAK/STAT signaling pathway has been selected and amplified in the long-term evolution of the transmission of cellular signaling. It participates in inflammation，immune regulation， and other links of diseases because of its simplicity and stability. Taking the JAK/STAT signaling pathway as the entry point and breakthrough can facilitate the summarization and discovery of the regulation modes of upstream and downstream targets under the micromechanism of psoriasis，and continuously promote the exploration and understanding of the mechanism of psoriasis. This study analyzed the targets of the JAK/STAT signaling pathway with the participation of Chinese medicinal compound preparations with clearing，resolving， and tonifying effects and monomers and main components，such as Ephedrae Herba，indirubin，magnolol，ginsenoside CK，shikonin，paeoniflorin，paeonol，and Tripterygium wilfordii glucosides. The results were integrated into the JAK/STAT signaling pathway family subtypes under the action of different inducers such as interleukin （IL）-6，IL-21，IL-22，IL-23，interferon-γ （IFN-γ）， and suppressors of cytokine signaling 1/3 （SOCS1/3） for the first time. Meanwhile， taking JAK/STAT signaling pathway as a specific reference means，this study discussed the differences in expression in the classification of psoriasis based on blood aspect and regional patient groups to provide references for further exploration of the mechanism and clinical targeted diagnosis and treatment of psoriasis.
