Prevention and Treatment of Diabetic Nephropathy by Regulating Endoplasmic Reticulum Stress with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20222241
- VernacularTitle:中医药调控内质网应激防治糖尿病肾病研究进展
- Author:
Zhengtao CHEN
1
;
Qingzhi LIANG
1
;
Yuan ZHANG
2
;
Yan YANG
1
;
Mengping WANG
1
;
Chunguang XIE
1
;
Hong GAO
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine， Chengdu 610075， China
2. First Affiliated Hospital of Army Medical University， Chongqing 400038， China
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
endoplasmic reticulum stress;
traditional Chinese medicine;
renal intrinsic cells
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(1):227-239
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy （DN） is one of the serious and common microvascular complications of diabetes mellitus （DM） and the main cause of end-stage renal disease （ESRD）. Endoplasmic reticulum stress （ERS） is a common stress defense mechanism in eukaryotic cells. In the ERS state， cells activate the unfolded protein response （UPR） to enhance the folding of unfolded proteins and the degradation of misfolded proteins， so as to restore the normal physiological function of the endoplasmic reticulum and avoid cell damage. However， excessive or chronic persistent ERS can induce apoptosis， inflammation， oxidative stress and other pathways to eventually cause cell damage. In recent years， a large number of studies have confirmed that ERS is closely associated with the occurrence and development of DN. In the case of DN， ERS is involved in the damage or protection of podocytes， glomerular mesangial cells， renal tubular epithelial cells， and glomerular endothelial cells. The regulation of ERS has become one of the hotspots in the prevention and treatment of DN and has received extensive attention in the field of traditional Chinese medicine. This paper systematically expounds the role of ERS in the occurrence and development of DN and summarizes the ERS-targeted regulation of DN by traditional Chinese medicine， with a view to providing certain research ideas for the prevention and control of DN with traditional Chinese medicine.
