Study on improvement effects of Citri Grandis Exocarpium extract on anorexia in immature rats
- VernacularTitle:化橘红提取物对幼龄大鼠厌食症的改善作用研究
- Author:
Jia LIU
1
,
2
;
Daoshun WU
1
;
Yunfeng PAN
1
;
Yanhui WANG
3
;
Yun LUO
1
;
Xiaobo SUN
1
Author Information
1. Institute of Medicinal Plant Development，Chinese Academy of Medical Sciences，Beijing 100193，China
2. School of Pharmacy，Guizhou University of Traditional Chinese Medicine，Guiyang 550025，China
3. Guangzhou Xiangxue Pharmaceutical Company Limited，Guangzhou 510663，China
- Publication Type:Journal Article
- Keywords:
Citri Grandis Exocarpium extract;
anorexia;
pepase;
gastrin;
motilin;
gastric inhibitory peptide
- From:
China Pharmacy
2022;33(23):2931-2935
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the pharmacodynamic effects of the Citri Grandis Exocarpium extract on anorexia model immature rats.METHODS Ten immature rats were randomly selected as the control group and given regular diet， while anorexia model was induced in the remaining 50 immature rats using the etiological simulation method. The immature model rats were divided into the model group， Jianwei xiaoshi tablet group （0.65 g/kg）， Citri Grandis Exocarpium extract low-dose， medium- dose and high-dose groups （0.5， 1.0， 2.0 g/kg）. After 14 d of continuous intragastric administration， the body mass and food intake of rats in each group were observed， and the gastric acid concentration， pepsinase activity， serum levels of gastrin （GAS）， motilin （MTL） and gastric inhibitory peptide （GIP） were measured. The histopathological changes in the gastric tissue were observed.RESULTS Compared with control group， the food intake， gastric acid concentration， pepsin activity， the levels of GAS and MTL were significantly decreased and GIP level was significantly increased in the immature rats of model group （P＜0.05）； gastric histopathological examination showed significant gastric mucosal congestion and loosening and detachment of epithelial cells. Compared with model group， all administration groups showed different degrees of improvement in the above indexes and decreased gastric histopathological damage after drug intervention.CONCLUSIONS Citri Grandis Exocarpium extract improves gastric motility and protects gastric mucosa in the immature rats by regulating the concentration of gastric acid， pepsin activity， the levels of GAS， MTL and GIP， thus improving anorexia in immature rats.
