Risk factor analysis of linezolid-induced hyponatremia and the establishment of its nomogram model
- VernacularTitle:利奈唑胺相关低钠血症危险因素分析及其列线图模型建立
- Author:
Yan QIN
1
;
Yanrong YE
1
;
Yun SHEN
1
;
Zhe CHEN
1
;
Huijie SHENG
1
;
Xiaoyu LI
1
;
Qianzhou LYU
1
Author Information
1. Dept. of Pharmacy，Zhongshan Hospital Affiliated to Fudan University，Shanghai 200032，China
- Publication Type:Journal Article
- Keywords:
linezolid;
hyponatremia;
risk factor;
adverse drug reaction;
nomogram model
- From:
China Pharmacy
2022;33(23):2891-2894
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the risk factors of linezolid-induced hyponatremia， and establish nomogram model of linezolid-induced hyponatremia.METHODS The clinical information of 142 patients who received linezolid therapy were collected from Zhongshan Hospital Affiliated to Fudan University from April 2019 to May 2021 including demographic characteristics， laboratory index， concomitant disease and drug combination. They were divided into hyponatremia group and non-hyponatremia group according to whether hyponatremia occurred； univariate analysis was used to compare the differences of variables between the two groups； the independent risk factors for linezolid-induced hyponatremia were analyzed by multivariate Logistic regression. The nomogram model was set up to identify the occurrence risk of linezolid-induced hyponatremia， receiver operating characteristic （ROC） curve and calibration curve， Hosmer-Lemeshow goodness-of-fit test were used to evaluate the predictive effectiveness of the model.RESULTS Of 142 patients， 30 patients suffered from hyponatremia， and 112 patients did not suffer， the incidence of adverse drug reaction was 21.1%. Univariate analysis showed that there was statistical significance in trough concentration of linezolid， baseline serum sodium， white blood cell count， total bilirubin， albumin， alanine aminotransferase， aspartate aminotransferase， combined use of spironolactone between hyponatremia group and non-hyponatremia group （P＜0.05）. Multivariate Logistic regression analysis showed that trough concentration of linezolid [OR＝1.128， 95%CI（1.028-1.239）]， baseline serum sodium [OR＝0.719， 95%CI（0.604-0.857）] and total bilirubin [OR＝1.007， 95%CI（1.002， 1.011）] were independent risk factors for linezolid-induced hyponatremia （P＜0.05）. The area under the ROC curve （95%CI） of the nomogram model was 0.874 （0.794-0.995）； the sensitivity and specificity were 88.4% and 76.7%. The average absolute error of calibration curve was 0.017. The results of Hosmer-Lemeshow goodness-of-fit test showed that there was no statistically significant difference between the predicted risk value and the measured value （χ 2＝4.941，P＝0.064）. CONCLUSIONS The trough concentration of linezolid， baseline serum sodium and total bilirubin are independent risk factors for linezolid-induced hyponatremia. The established nomogram model shows well predictive performance to identify linezolid-induced hyponatremia.
