Research progress on the molecular mechanism of periodontal pathogens promoting the development of cardiovascular diseases
10.12016/j.issn.2096-1456.2023.02.011
- Author:
LUO Kaihua
1
,
2
;
PENG Xian
1
,
3
;
LI Jiyao
1
,
2
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Clinical Research Center for Oral Diseases, Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University
3. National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
periodontitis / cardiovascular disease / atherosclerosis / Porphyromonas gingivalis / bacteremia / systemic inflammatory state / immune disorders / molecular mimicry / apolipoprotein E
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(2):147-152
- CountryChina
- Language:Chinese
-
Abstract:
Periodontitis is a multifactorial infectious and inflammatory disease occurring in tooth-supporting tissues. In recent decades, many studies have reported a potential relationship between periodontitis and cardiovascular disease, and periodontal pathogens are an important factor linking periodontitis and cardiovascular disease. In this review, we summarize updated preclinical studies and epidemiological evidence on the association of these two diseases. Moreover, possible mechanisms accounting for such links are introduced, including bacteremia and direct invasion of pathogens, endotoxemia caused by virulence factors of periodontal pathogens leading to systemic inflammation, abnormal lipid metabolism and oxidative stress, which further affect the inflammatory states of the cardiovascular system. The molecular mimicry theory and the intrinsic correlation of apolipoprotein E between periodontitis and cardiovascular disease require further study. Combined with existing studies, it is reasonable to assume that periodontal treatment and oral hygiene can reduce the risk of cardiovascular disease in patients with periodontitis. More studies are needed to focus on the molecular mechanism linking periodontal pathogens and cardiovascular diseases. These studies will provide evidence that periodontal pathogens directly invade the cardiovascular system or indirectly invade host cells as well as isolate and culture bacteria from the tissues of lesions. Studies should also explore how the local inflammatory state, periodontal pathogens and their products directly influence cardiovascular disease-related biomarkers (C-reactive protein, vascular endothelial growth factor, heat shock protein, etc.) and the mechanism. This information may provide a reference for the effective prevention and treatment of periodontitis and cardiovascular disease in the future.
- Full text:牙周致病菌促进心血管疾病发生发展的分子机制研究进展.pdf
