Research progress on m6A-modified circRNA in oral diseases
10.12016/j.issn.2096-1456.2023.02.009
- Author:
YANG Jingwen
1
,
2
;
ZHOU Haiwen
1
,
2
Author Information
1. Department of oral mucosal diseases, Shanghai Ninth People'
2. s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong UniversityNational center for Stomatoloy, National Clinical Research Center for oral diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology
- Publication Type:Review
- Keywords:
circular RNA / noncoding RNAs / methylated modification / N6-methyladenosine / oral squamous cell carcinoma / oral potential malignant diseases / oral / tumour / biomarkers
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(2):137-141
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine (m6A) modification is the most abundant RNA modification in eukaryotes and is widely involved in the regulation of RNA nuclear export, splicing, translation and degradation. Increasing evidence shows that m6A methylation modification of circular RNA (circRNA) has great potential in metabolism, immunity and benign and malignant diseases. Here, we review the research status of circRNA m6A methylation modification in physiological processes, malignant tumors and oral diseases. It has been shown that m6A methylation can regulate circRNA by regulating circRNA translation, promoting circRNA nuclear output, and promoting circRNA degradation; M6A-modified circRNA plays a regulatory role in immunity, the reproductive system, myogenesis and development, and malignant tumors; and the M6A methyltransferase METTL3 promotes the occurrence of oral squamous cell carcinoma (OSCC) through m6A modification mediated by YTHDF1. The high expression of METTL14 can effectively reduce the proliferation, migration and invasion of OSCC. There is little research on circRNA m6A methylation modification in the oral cavity, which is limited to preliminary research in ameloblastoma and oral implant bone absorption. It has broad research prospects in the treatment of major oral diseases (such as potential oral malignant diseases and OSCC).
- Full text:环状RNA m6A甲基化修饰在口腔疾病中的研究进展.pdf
