Advances of the mechanism study on Chinese herb monomers in improving premature ovarian failure
- VernacularTitle:中药单体改善卵巢早衰的作用机制研究进展
- Author:
Rugen YAN
1
;
Yuqi WANG
2
;
Jing HE
2
;
Yin CHEN
3
;
Pingping CAI
4
;
Changzhong LI
4
Author Information
1. School of Traditional Chinese Medicine & School of Integrated Chinese and Western Medicine，Nanjing University of Chinese Medicine，Nanjing 210023，China
2. The First Clinical Medical College，Shandong University of Traditional Chinese Medicine，Jinan 250355，China
3. Dept. of Obstetrics and Gynecology，Xuyi County Hospital of Chinese Medicine，Jiangsu Xuyi 211700，China
4. Dept. of TCM，Shandong Provincial Hospital Affiliated to Shandong First Medical University，Jinan 250012，China
- Publication Type:Journal Article
- Keywords:
premature ovarian failure;
Chinese herb monomers;
mechanism of action
- From:
China Pharmacy
2022;33(21):2685-2688
- CountryChina
- Language:Chinese
-
Abstract:
Premature ovarian failure （POF） is a common gynecological endocrine disease ，which can cause follicular development stagnation or premature failure in the ovary ，leading to ovarian function loss ，and seriously affecting women ’s physical and mental health . Traditional Chinese medicine shows less toxicity and side effects but significant effect in the treatment of POF . Chinese herb monomers are the active ingredients of traditional Chinese medicine that exert their effects ，and their chemical structure are determined . From the perspective of Chinese herb monomers ，the author reviewed the mechanism of their effect on improving POF . The results showed that icariin ，quercetin，resveratrol and ginsenoside Rg 1 could improve the ovarian function of POF model animals by activating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway ，inhibiting oxidative stress and apoptosis of granulosa cells ，promoting ovarian autophagy ，and regulating the level of sex hormones ；puerarin and resveratrol can improve the ovarian function of POF model by interfering with Wnt/ β-catenin signaling pathway ，reducing oxidative stress response ，and inhibiting follicular atresia . Although the Chinese herb monomers have certain effect in improving POF，most of them remain in the experimental stage ，and the clinical efficacy in improving POF cannot be objectively evaluated . In the future ，the development of new dosage forms of Chinese herb monomers should be strengthened to lay a foundation for the development of new drugs for treating POF .
