Clinical pharmacists participating in pharmaceutical consultation of one case of disseminated neonatal herpes simplex virus type Ⅱ infection
- VernacularTitle:临床药师参与1例新生儿播散性Ⅱ型单纯疱疹病毒感染的药学会诊
- Author:
Na LI
1
;
Ze ZOU
1
;
Fabing PENG
2
;
Xin WANG
3
;
Fei LI
1
;
Qian XIE
1
Author Information
1. Dept. of Pharmacy，Qianjiang Central Hospital of Chongqing，Chongqing 409099，China
2. Dept. of Neonatology，Qianjiang Central Hospital of Chongqing，Chongqing 409099，China
3. Dept. of Obstetrics，Qianjiang Central Hospital of Chongqing，Chongqing 409099，China
- Publication Type:Journal Article
- Keywords:
type Ⅱ herpes simplex virus;
clinical phar -
- From:
China Pharmacy
2022;33(21):2676-2680
- CountryChina
- Language:Chinese
-
Abstract:
This paper describes the clinical pharmacists ’participation in the diagnosis and treatment for a case of disseminated neonatal herpes simplex virus （HSV）type Ⅱ infection with fever as the initial symptom and without skin and mucous membrane involvement. Clinical pharmacists assessed the newborn ’s condition ，inquired about the disease history and medication status of the child’s mother hospitalized in the department of obstetrics ，reviewed the literature ，analyzed that the fever of the child might be related to the medical history of the mother ，and considered that the child might have neonatal HSV infection . It was suggested to use acyclovir 20 mg/kg intravenously for q 8 h immediately after completing virus -related testing ，and closely monitor the common adverse drug reactions of acyclovir . The doctors accepted the consultation advice . The newborn was diagnosed as disseminated neonatal HSV type Ⅱ infection. After treatment ，the child ’s condition was relatively stable and the doctors consulted clinical pharmacists again to help formulate the follow -up drug treatment plan and monitoring plan for the patient . After reviewing relevant literature，clinical pharmacists suggested that after 21 days of intravenous acyclovir treatment ，oral acyclovir 300 mg/m2 q8 h should be continued for 6 months；moreover，common adverse drug reactions should be monitored and neurological development should be evaluated during oral acyclovir treatment ，all of which were accepted by physicians . No adverse drug reactions occurred during intravenous administration of acyclovir ， serum creatinine and urea increased in the 4th week of oral acyclovir administration，but returned to normal after drug withdrawal . The baby was followed up to 1 year old ，and the prognosis was good without neurological sequelae . Clinical pharmacists enabled the clinicians to clarify the treatment strategy and also reduced the risk of medication for the patient by participating in the pharmaceutical consultation . Clinical pharmacists play an cstc active and effective role in the medication treatment ，which fully embodies the professional value in multidisciplinary collaborative diagnosis and treatment .
