Change of neutrophil count after treatment of intravenous immunoglobulin in children with idiopathic thrombocytopenic purpura.
10.3345/kjp.2008.51.2.204
- Author:
Jun Young PARK
1
;
Ji Ae PARK
;
Seong Shik PARK
;
Young Tak LIM
Author Information
1. Department of Pediatrics, Pusan National University College of Medicine, Busan, Korea. limyt@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Neutropenia;
Intravenous immunoglobulin;
Idiopathic thrombocytopenic purpura
- MeSH:
Child;
Hand;
Humans;
Immunoglobulins;
Immunoglobulins, Intravenous;
Incidence;
Isoantibodies;
Neutropenia;
Neutrophils;
Purpura, Thrombocytopenic, Idiopathic
- From:Korean Journal of Pediatrics
2008;51(2):204-208
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to investigate the incidence and course of neutropenia following intravenous immunoglobulin (IVIG) therapy in children with idiopathic thrombocytopenic purpura (ITP). METHODS: From January 2001 to June 2006, fifty-four patients with ITP were enrolled in this study. Forty-two of 54 patients were treated with IVIG, while the other 12 were treated with anti-D immunoglobulin (Anti-D Ig). Post-treatment absolute neutrophil counts (ANC) were compared between patients who received IVIG and those who received Anti-D Ig. Comparison of post-treatment ANC between patients who treated with two different IVIG regimens (400 mg/kg/day for 5 days and 1 g/kg/day for 2 days) was also performed. RESULTS: Pretreatment ANC were not significantly different between the two treatment groups. After treatment with IVIG, 32 out of 42 patients (76.2%) showed more than 50% decrease of ANC from the baseline. On the other hand, only 2 out of 12 patients (16.7%) showed more than 50% decrease of ANC from the baseline after treatment Anti-D Ig. No significant difference was observed in the decline of ANC between the first IVIG treatment (42 patients) and repeated IVIG treatment groups (7 patients). There was no statistical difference in post-treatment ANC between patients who treated with two different IVIG regimens. The neutropenia induced by IVIG had resolved spontaneously in 38 out of 39 patients (97%) after several days. CONCLUSION: Neutropenia following IVIG administration may not be an uncommon finding in children with ITP. It seems to be transient and self limited.
