Bibliometric analysis of traditional Chinese medicines for myocardial ischemia-reperfusion injury
- VernacularTitle:中药防治心肌缺血再灌注损伤的文献计量学分析
- Author:
Xiang QI
1
;
Jianqi LU
2
;
Yuhan WANG
3
;
Shangzhi WU
4
;
Zhixiong JIANG
1
;
Zhide ZHU
5
;
Xiaoling HE
1
Author Information
1. School of Graduate，Guangxi University of Chinese Medicine，Nanning 530200，China
2. Dept. of Cardiology，the First Affiliated Hospital of Guangxi University of Chinese Medicine/Branch Center of National Clinical Medical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine，Nanning 530200，China
3. School of Pharmacy，Guangxi University of Chinese Medicine，Nanning 530200，China
4. School of Basic Medicine，Guangxi University of Chinese Medicine，Nanning 530200，China
5. Museum of Guangxi University of Chinese Medicine，Nanning 530200，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
myocardial ischemia -reperfusion injury;
cardiovascular disease;
bibliometrics
- From:
China Pharmacy
2022;33(21):2590-2596
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the current status and research hot spots of traditional Chinese medicine （TCM）in the prevention and treatment of myocardial ischemia -reperfusion injury （MIRI），and to provide reference for developing relevant studies. METHODS A bibliometric analysis was performed with the literature on TCM treatments for MIRI included in the Web of Science as the data source . RESULTS A total of 972 literatures were included in this study . The research on TCM for prevention and treatment of MIRI in recent 10 years showed an increasing trend year by year ，and the literature published in 2021 were cited most frequently ；most research scholars focused in China ；Peking Union Medical College ，Chinese Academy of Medical Sciences had the most papers in this field ，and a lot of collaboration with other institutions ，which had a large influence in the field ；Sun Guibo and Sun Xiaobo were high -yielding authors in the field ，but the global authorship was not very close and had not formed cooperative teams of some scale ；Molecular Medicine Reports was perhaps the most popular journal in the field . Co-citation analysis found that the research direction in this field was mostly focused on exploring the pathogenesis of MIRI and finding intervention targets . Key words analysis revealed that TCM regulated apoptosis ， pyroptosis， mitochondrial dysfunction ， miRNA and other pathways to improve MIRI research was a hot spot in the field ，and more studies had focused on the Nrf 2 pathway，NF-κB pathway ，NLRP3 inflammasomepathway， TNF pathway ， SIRT3 pathway， JNK pathway ，PI3K/Akt pathway and AMPK pathway . CONCLUSIONS Much attention has been paid to the prevention and treatment of MIRI by TCM in the past 10 years，and the current hot spots in this field are mostly focused on the studies about the intervention mechanism of TCM ’s active ingredients and Chinese patent medicines on MIRI . Moreover，the research about TCM in the treatment of MIRI is mostly focused on the field of basic experiments at present ，and it is recommended that many large -scale，high-quality， multicenter，randomized controlled clinical studies should be carried out in the future ，to provide high -grade evidence -based evidence for the application of TCM in clinic .
