Optimization of drying methods of Compound Scutellaria baicalensis extract powder
- VernacularTitle:复方黄芩浸膏粉干燥方式的优选
- Author:
Yupu HUANG
1
,
2
;
Dazhang WU
1
,
3
;
Yumei TANG
1
;
Sen WANG
1
;
Yu WANG
2
Author Information
1. College of Pharmacy，Zunyi Medical University，Guizhou Zunyi 563003，China
2. Dept. of Pharmacy，Sichuan Second Hospital of TCM，Chengdu 610031，China
3. Chongqing Tong Junge Pharmaceutical Co.，Ltd.，Taiji Group，Chongqing 401366，China
- Publication Type:Journal Article
- Keywords:
Compound Scutellaria baicalensis prescription
- From:
China Pharmacy
2022;33(22):2748-2752
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To optimize the drying methods of Compound Scutellaria baicalensis extract powder. METHODS Compound S. baicalensis extract powder was prepared by atmospheric pressure drying， decompression drying and spray drying respectively， and high-performance liquid chromatography （HPLC） fingerprint of the extract powder was established. The physical fingerprint of the extract powder was established by 13 secondary indexes， such as particle size， particle size distribution and bulk density. HPLC fingerprints and physical fingerprints of 3 kinds of extract powders were compared by similarity evaluation method； through the conversion of the secondary indexes， five primary indexes of homogeneity， stacking， compressibility， fluidity and stability were calculated， and the physical properties of 3 kinds of extract powder were evaluated. The compressibility parameters of 3 kinds of extract powder such as index of parameter （IP）， index of parametric profile （IPP） and index of good compression （IGC） were calculated by the secondary index to evaluate the compression formability of the powder. RESULTS The similarity means of HPLC fingerprint of the extract powder obtained by atmospheric pressure drying， decompression drying and spray drying were 0.74， 0.90 and 0.94， respectively， and the similarity means of physical fingerprint were 0.74， 0.83 and 0.92， respectively. The overall similarity of spray drying extract powder was higher. The results of physical fingerprint analysis showed that the physical properties of the extract powder obtained by different drying methods were different. The 3 kinds of extract powder showed poor stability but good stacking. The homogenity and compressibility of extract powder by spray drying and decompression drying were better than those by atmospheric pressure drying， but the fluidity was worse than that by atmospheric pressure drying. The results of further compression formability analysis showed that the IP of spray drying extract powder was 0.54， IPP was 5.23， IGG was 5.03， and the spray drying extract powder could be directly pressed after adding a small amount of lubricant. CONCLUSIONS There are differences in HPLC and physical fingerprints of Compound S. baicalensis extract powder obtained by different drying methods. The spray drying extract powder possesses better Δ 基金项目 四川省公益性科研院所基本科研项目 （No.2022- 4-720） overall quality， which is more suitable for the drying of ＊第一作者副主任药师。研究方向：临床药学、药事管理、药物研 Compound S. baicalensis extract powder. 究。E-mail：hyptotti@163.com
