Comparative analysis of antibacterial drugs between the 2021 edition of WHO Model List of Essential Medicines for Children and the 2018 edition of National Essential Medicines List of China
- VernacularTitle:2021年版WHO儿童基本药物示范目录与2018年版国家基本药物目录中抗菌药物的比对分析
- Author:
Jinfen ZHANG
1
;
Ruofei TONG
1
;
Jigang DONG
1
;
Yanyan SUN
1
Author Information
1. Dept. of Pharmacy，Tianjin Children’s Hospital/ Tianjin University Children’s Hospital，Tianjin 300134，China
- Publication Type:Journal Article
- Keywords:
WHO Model List of Essential Medicines for
- From:
China Pharmacy
2022;33(22):2694-2699
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To compare the antibacterial drugs between the 2021 edition of WHO Model List of Essential Medicines for Children （WHO EMLc） and the 2018 edition of National Essential Medicines List of China （NEML）， and provide reference for the drug selection of Chinese essential medicine list for children. METHODS By means of descriptive analysis， the similarities and differences in classification methods， special markers， the varieties， dosage forms and specifications were compared between WHO EMLc and NEML. RESULTS WHO EMLc had strict limits and classifications on the antibacterial drugs， marked the age and weight of children who were restricted to use， and focused on the drug resistances and safety in children. In terms of varieties， there were 51 kinds of antibacterial drugs in NEML and 62 in WHO EMLc； 36 kinds of antibacterial drugs were both included in NEML and WHO EMLc； some antibacterial drugs， such as cloxacillin， procaine penicillin and ceftazidime avibactam， were listed in WHO EMLc but not in NEML. In terms of dosage forms， the dosage forms of antibacterial drugs included in WHO EMLc were more abundant and flexible， such as oral liquids， powder for oral liquids and scored tablets which were not included in NEML， and could improve the compliance of children’s medication and the accuracy of dosage. In terms of specifications， the total numbers of the specifications of antibacterial drugs both included in the two lists were close， but the specifications of some drugs included in NEML were more abundant， and the minimum specifications included in NEML were smaller. Although some of the unique antibacterial drugs included in WHO EMLc were listed in China， they could not be used in children due to the lack of drug data on children in China， such as clofazimine， bedaquinoline and delamanid. CONCLUSIONS The antibacterial drugs included in NEML can not fully meet the medication needs of children in China. WHO EMLc has certain advantage and rationality as a special list for children. The relevant departments in China can learn from the excellent experience of WHO EMLc， improve the information of pediatric medication of NEML and launch Chinese Essential Medicine List for Children as soon as possible.
