Early intervention of uric acid in elderly high risk population of coronary heart disease
10.3969/j.issn.1006-2483.2022.06.032
- VernacularTitle:老年冠心病高危人群尿酸早期干预的研究
- Author:
Juan CHEN
1
;
Xiao-feng MA
1
;
Guang-dong SHE
2
Author Information
1. Department of Health Care for Cadres , Department of Cardiovascular and Cerebrovascular , Xining , Qinghai 810099 , China
2. Department of Cardiovascular and Cerebrovascular Diseases ,Xining , Qinghai 810099 , China
- Publication Type:Journal Article
- Keywords:
Elderly people;
Coronary heart disease;
Uric acid;
Early intervention
- From:
Journal of Public Health and Preventive Medicine
2022;33(6):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of early intervention of uric acid in elderly high-risk patients with coronary heart disease. Methods Patients who visited the Cardiovascular Department/Cardiology Department of our hospital from January 2017 to December 2019 were screened, and 456 patients who met the criteria were included in the study. The included patients were randomly divided into a control group and an observation group, with 228 cases in each group. The control group was given routine intervention, and the observation group was given early uric acid intervention. The levels of uric acid, cardiac function indexes, 2-year incidence of coronary heart disease and incidence of cardiovascular events were compared between the two groups before and after the intervention. Results After the intervention, the cognitive level of the two groups was significantly improved, and the understanding level of the observation group was significantly higher than that of the control group (P<0.001). Compared with the control group, the abnormal rate of uric acid level in the observation group was significantly lower (P<0.015). After intervention, the ejection fraction, cardiac output and total peripheral vascular resistance in the observation group had no significant changes (P>0.05). In the control group, ejection fraction and cardiac output decreased, total peripheral vascular resistance increased, and the difference was statistically significant (P<0.05). After 2 years of intervention, 94 cases (41.23%) of coronary heart disease in the control group and 48 cases in the observation group had the disease. (21.05%), the difference between the two groups was significant (P=0.002); within 2 years after the intervention, 78 cases/time (34.21%) of cardiovascular events occurred in the control group and 40 cases/time (17.54%) in the observation group, with a difference between the two groups (P=0.007).Conclusion Early intervention of uric acid in elderly high-risk coronary heart disease population can significantly reduce uric acid levels, stabilize cardiac function indicators, and reduce the 2-year incidence of coronary heart disease and cardiovascular events, which can provide a reference for clinical disease intervention in high-risk coronary heart disease populations.
