Clinical characteristics of hand-foot-and-mouth disease in children caused by Coxsackie A6 virus
10.3969/j.issn.1006-2483.2022.06.031
- VernacularTitle:柯萨奇A6病毒致儿童手足口病的临床特征分析
- Author:
Min SUN
1
;
Jian-hong SUN
1
;
Yan-hua WANG
1
;
Jin-hua HUANG
1
;
Fang XIE
1
Author Information
1. Department of Pediatrics , Characteristic Medical Center of PAPF , Hedong , Tianjin 300162 , China
- Publication Type:Journal Article
- Keywords:
Coxsackie virus A6;
Hand-foot-mouth disease;
Complications
- From:
Journal of Public Health and Preventive Medicine
2022;33(6):132-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of Coxsackie virus A6 (CV-A6)- related pediatric hand-foot-and-mouth disease (HFMD). Methods The data of all children patients with HFMD infected with CV-A6 in our hospital from January 2017 to December 2020 were collected. According to the clinical manifestations, the patients were divided into common type and severe type. The clinical and laboratory manifestations of the two groups were compared. Results A total of 247 children with HFMD infected with CV-A6 were included, of which 78.95% (195 / 247) were common type and 21.05% (52/247) were severe type. Most cases of CV-A6 related critical HFMD were characterized by high fever, rash, age less than 36 months, and elevated leukocyte and C-reactive protein levels. Critically ill HFMD patients had higher male proportion, long-term fever, loss of appetite, enlarged tonsils, diarrhea, vomiting, elevated levels of creatine kinase and blood glucose, and higher positive proportion of fecal occult blood (P < 0.05). The main complications of critically ill patients were aseptic meningitis (27/52, 51.92%) and pulmonary edema (5/52, 9.62%). Conclusion Critical HFMD patients caused by CV-A6 should not be ignored. Aseptic meningitis and pulmonary edema are the main complications.
