Effect of Sarcoplasmic Reticulum Ca2 +-ATPase Overexpression on Neuroendocrine System in Chronic Heart Failure Beagles

VernacularTitle:过表达肌浆网Ca2+-ATP酶对慢性心力衰竭犬神经内分泌系统的影响
Author: Zhiqing FU ; Xiaoying LI ; Xiaochun LU ; Yafei MI ; Shengan ZHOU
Publication Type:Journal Article
Keywords: chronic heart failure, sarcoplasmic reticulum Ca2+-ATPase, overexpression, neuroendocrine system
From: Chinese Journal of Rehabilitation Theory and Practice 2013;19(2):129-131
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) overexpression on neuroendocrine system in chronic heart failure beagles. Methods The cardiac contraction function of chronic heart failure beagles were assessed by echocardiography before and after SERCA2a gene transduction. Radiation immune method was used to test the serum level of neuroendocrine factors such as Angiotensin Ⅱ, atrial natriuretic peptide, endothelin-1 and TNF-α, IL-6. Results The cardiac contraction function of chronic heart failure beagles improved greatly (P<0.05), and the serum levels of neuroendocrine factors significantly reduced after SERCA2a overexpression (P<0.05). Conclusion The vicious circle of neuroendocrine system may be blocked partially by SERCA2a overexpression.