Effect of Morroniside on Blood Viscosity in Focal Cerebral Ischemia/Reperfusion in Rats

VernacularTitle:莫诺苷对局灶性脑缺血再灌注大鼠血液黏度的影响
Author: Hong PAN ; Fangling SUN ; Xiaofeng WANG ; Wen WANG ; Houxi AI ; Li ZHANG ; Yi AN
Publication Type:Journal Article
Keywords: morroniside, ischemia/reperfusion, blood viscosity, plasma viscosity, rats
From: Chinese Journal of Rehabilitation Theory and Practice 2013;19(2):107-109
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of morroniside on blood viscosity in focal cerebral ischemia/reperfusion in rats. Methods The animal model was induced with occlusion of middle cerebral artery (MCAO), and morroniside (30 mg/kg, 90 mg/kg, 270 mg/kg) was then administered intragastrically for 7 d. Whole blood viscosity and plasma viscosity were detected with auto-hemorheological instrument and microplasma testing device. Results Compared with sham-operated group, both whole blood viscosity and plasma viscosity significantly increased in ischemic rats (P<0.001); however, morroniside reduced whole blood and plasma viscosity noticeably (P<0.001). Conclusion Morroniside can inhibit the increase of blood viscosity induced by focal cerebral ischemia/reperfusion in rats.