Effect of Morroniside on Coagulation in Focal Cerebral Ischemia/Reperfusion in Rats

VernacularTitle:莫诺苷对局灶性脑缺血再灌注大鼠凝血四项的影响
Author: Tingwei YUAN ; Fangling SUN ; Xiaofeng WANG ; Houxi AI ; Wen WANG ; Dachun GONG
Publication Type:Journal Article
From: Chinese Journal of Rehabilitation Theory and Practice 2013;19(2):104-106
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of morroniside on fibrinogen (Fib), prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) in focal cerebral ischemia/reperfusion in rats. Methods The animal model was induced with occlusion of middle cerebral artery (MCAO) with suture embolus, and morroniside was then administered intragastrically at the dose of 30, 90 and 270 mg/kg for 7 d. Acetyl salicylic acid was taken as positive control drug. The content of Fib, and PT, APTT and TT were measured withrelated kits. Results Compared with the sham-operated group, the concentration of Fib significantly increased (P<0.001) and PT, APTT and TT significantly shortened in the model group (P<0.001); however, compared with the model group, morroniside significantly decreased Fib content (P<0.01) and prolonged PT, APTT and TT (P<0.05). Conclusion Morroniside can antagonize the coagulation function in focal cerebral ischemia/reperfusion in rats.