Effect of Morroniside on Platelet Aggregation in Focal Cerebral Ischemia/Reperfusion in Rats

VernacularTitle:莫诺苷对二磷酸腺苷诱导局灶性脑缺血再灌注大鼠血小板聚集的影响
Author: Hua CHENG ; Fangling SUN ; Xiaofeng WANG ; Houxi AI ; Li ZHANG ; Naihong CHEN ; Wen WANG
Publication Type:Journal Article
Keywords: morroniside, adenosine diphosphate, platelet aggregation, ischemia/reperfusion, rats
From: Chinese Journal of Rehabilitation Theory and Practice 2013;19(2):101-103
CountryChina
Language:Chinese
Abstract: Objective To explore the effects of morroniside on platelet aggregation induced by adenosine diphosphate (ADP) in focal cerebral ischemia/reperfusion in rats. Methods 48 Sprague-Dawley rats were randomly divided into sham group, model group, morroniside dose groups (30 mg/kg, 90 mg/kg, 270 mg/kg) and acetyl salicilic acid (ASA) group (10 mg/kg). The model of middle cerebral artery occlusion (MCAO) was established in all rats except the sham group. Born's turbidimetry was used to measure platelet aggregation rate in rats of MCAO model (in vivo). Results Compared with the model group, the platelet aggregation decreased significantly in the morroniside high dose group (P<0.001). Conclusion Morroniside has the effect of anti-platelet aggregation in focal cerebral ischemia/reperfusion in rats.