Comparison of efficacy of different doses of Conbercept combined with panretinal photocoagulation and EX-PRESS glaucoma shunt implantation in the treatment of neovascular glaucoma
10.3980/j.issn.1672-5123.2022.12.24
- VernacularTitle:注射不同剂量康柏西普联合PRP及EX-PRESS引流钉植入术治疗NVG的疗效对比
- Author:
Su-E ZHONG
1
;
Sheng HUANG
1
;
Mang-Qian RAO
1
;
Wen-Qiang ZHANG
1
Author Information
1. Department of Ophthalmology, Tongren City People's Hospital, Tongren 554300, Guizhou Province, China
- Publication Type:Journal Article
- Keywords:
EX-PRESS glaucoma shunt;
neovascular glaucoma;
Conbercept;
panretinal photocoagulation;
intravitreal injection
- From:
International Eye Science
2022;22(12):2058-2062
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the efficacy and safety of three doses of Conbercept intravitreal injection with panretinal photocoagulation(PRP)followed by EX-PRESS glaucoma shunt implantation on patients with neovascular glaucoma(NVG).METHODS: Prospective study. A total of 37 patients(37 eyes)with NVG from May 2018 to September 2020 were collected. All accepted intravitreal injection of Conbercept and PRP 3-5d later, and accepted EX-PRESS glaucoma shunt implantation within 1wk after surgery. They were randomly divided into the low-dose group(13 eyes), the conventional dose group(12 eyes)and the high-dose group(12 eyes)according to three doses of preoperative Conbercept intravitreal injection, and they were injected with 10mg/mL Conbercept of 0.03, 0.05 and 0.08 mL(0.3, 0.5 and 0.8 mg Conbercept contained)respectively. The regression of iris and angle neovascularization(NV)after intravitreal injection was observed in the three groups, and postoperative intraocular pressure(IOP), best corrected visual acuity(BCVA)and complications were compared among the three groups.RESULTS: All patients completed follow-up. Cases with NV regression of iris and angle in the high-dose group were significantly more than the low-dose group(χ2=0.132, P=0.003)and the conventional dose group(χ2=0.154, P=0.015)3-5d after intravitreal injection. BCVA and IOP of the three groups at 1, 3 and 6mo after surgery were improved compared with those before treatment. IOP of the low-dose group, the conventional dose group and the high-dose group at 12mo after surgery was 14.12±2.63, 13.37±2.18 and 12.15±1.43mmHg, respectively. IOP of the high-dose group was lower than that of the low-dose group and the conventional dose group(all P<0.05). The BCVA of the high-dose group at 12mo after surgery was better than that of the low-dose group and the conventional dose group(all P<0.05). There was no significantly statistical difference in the incidence of postoperative complications at 12mo after surgery among the three groups(P>0.05).CONCLUSIONS: The intravitreal injection of high-dose(0.8mg)Conbercept combined with PRP and EX-PRESS glaucoma shunt implantation has particularly significant clinical effect on the treatment of NVG.
