Traditional Chinese Medicine Intervention in Ulcerative Colitis Based on JAK/STAT Pathway： A Review
10.13422/j.cnki.syfjx.20221516
- VernacularTitle:基于JAK/STAT通路的中医药干预溃疡性结肠炎研究进展
- Author:
Jinxin WANG
1
;
Sheng XIE
2
;
Liqun LI
2
;
Xiaoyan HUANG
2
;
Maoguang HUANG
1
;
Feng LUO
1
;
Yueying CHEN
1
;
Jinjing TAN
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine，Nanning 530001，China
2. The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530001，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
Janus kinase（JAK）;
signal transducer and activator of transcription（STAT）;
ulcerativecolitis（UC）;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(24):274-282
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis（UC）is a disease characterized by chronic persistent inflammation of the colorectal mucosa. Its complex pathological mechanism is related to immune inflammation and enhanced apoptotic activity. The Janus kinase（JAK）/signal transducer and activator of transcription（STAT）is an important regulatory pathway in the body's physiological function, which can regulate the release of intestinal pro-inflammatory factors and induce apoptosis, resulting in colon tissue damage. In the condition of UC, the biological activities and expression levels of JAK and STAT increased, and the tissue inflammatory response and apoptosis rate increased, which led to the destruction of intestinal mucosal tissues. At present, in the treatment of UC, glucocorticoids and immunosuppressants are mainly employed to reduce intestinal inflammation. Although they can block the progress of UC to some extent, the adverse reactions are severe. A large number of studies have shown that traditional Chinese medicine（TCM） has significant advantages in the prevention and treatment of UC and can significantly reduce the recurrence rate of this disease. In recent years, plenty of studies have been carried out to explore the role of TCM in the treatment of UC by regulating the JAK/STAT pathway. The results have shown that the JAK/STAT pathway is the key target pathway of TCM in the treatment of UC. Based on the etiology and pathogenesis of deficiency and excess, TCM regulates the JAK/STAT pathway by clearing heat, drying dampness, cooling and activating blood, invigorating the spleen, warming the kidney, and performing both tonification and elimination to maintain the balance between pro-inflammatory factors and anti-inflammatory factors, weaken colonic inflammatory response, inhibit apoptosis, and play a role in the treatment of UC. The present study analyzed the mechanism and effect of TCM in intervening in UC by targeting the JAK/STAT signaling pathway and summarized the molecular mechanisms of different cytokines such as interleukin-6（IL-6）, IL-10, IL-23, microRNA（miRNA）-146a, and suppressors of cytokine signaling 2/3（SOCS2/3） on many family subtypes of the JAK/STAT signaling pathway to facilitate the comprehensive understanding of researchers on the mechanism of TCM on the JAK/STAT pathway in UC, which is expected to provide a theoretical basis for the treatment of UC and further drug development.
