Prevention and Treatment of Renal Tubular Injury in Diabetic Kidney Disease with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20222139
- VernacularTitle:中医药防治糖尿病肾脏病肾小管损伤的研究进展
- Author:
Jingyan LIANG
1
;
Dongyang WU
2
;
Yiming SUN
1
;
Jia LUO
1
;
Yan ZHOU
1
;
Guodong HUANG
1
Author Information
1. Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine， Nanning 530201，China
2. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica， Guangxi University of Chinese Medicine， Nanning 530200，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
diabetic kidney disease;
renal tubular injury;
clinical research;
fundamental research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(24):261-273
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney diseases （DKD） is one of the main microvascular complications of diabetes. According to the available studies， the initial factor of DKD is glomerular injury. However， in recent years， more and more studies have confirmed that renal tubular injury plays a key role in the development of DKD. Taking renal tubules and their interstitium as therapeutic targets has become a new idea for the treatment of DKD. Traditional Chinese medicine （TCM） can treat renal tubular injury in DKD via multiple pathways， targets， and links， demonstrating significant therapeutic effect and slight side effects. According to the etiology and pathogenesis of DKD， doctors differentiate different syndromes such as deficiency of both Qi and Yin， deficiency of spleen and kidney Yang， and Qi deficiency and blood stasis and then adopt the therapies of nourishing kidney and strengthening essence， clearing heat and eliminating dampness， tonifying Qi and nourishing yin and so on， which have shown significant effect in the treatment of renal tubular injury in DKD. This paper summarizes the experimental studies about the treatment of renal tubular injury in DKD by TCM compound prescriptions， as well as the effective parts， extracts， and active ingredient of Chinese herbal medicines. Chinese herbal medicines and their derivates can regulate Toll-like receptor 4 （TLR4）/nuclear factor-κB （NF-κB）， nuclear factor erythroid 2-related factor 2 （Nrf2）/antioxidant response element （ARE）， transforming growth factor-β1 （TGF-β1）/Smads and other signaling pathways to treat renal tubular injury from resisting oxidative stress， inhibiting apoptosis of renal tubular epithelial cells， and blocking renal tubular epithelial-mesenchymal transformation. With this review， we hope to provide a theoretical basis for the development and clinical application of new drugs for renal tubular injury in DKD.
