Antiviral and Antibacterial Effect of Chicoric Acid： A Review
10.13422/j.cnki.syfjx.20222242
- VernacularTitle:菊苣酸抗病毒及抗菌作用研究进展
- Author:
Chao WU
1
;
Junqiang LI
2
;
Xiaojuan CONG
3
;
Yuan GAO
3
;
Fei YU
3
;
Yanyu LYU
3
;
Min YANG
1
;
Jian LI
4
;
Shuai FENG
1
;
Feng LI
1
Author Information
1. Shandong University of Traditional Chinese Medicine（TCM）， Jinan 250355， China
2. Yantai Center for Food and Drug Control， Yantai 264000， China
3. Shandong Drug and Food Vocational College， Weihai 264210， China
4. Affiliated Hospital of Shandong University of TCM， Jinan 250355， China
- Publication Type:Review
- Keywords:
chicoric acid;
antiviral effect;
antibacterial effect;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(24):220-228
- CountryChina
- Language:Chinese
-
Abstract:
Chicoric acid， a hydroxycinnamic acid with the molecular formula C22H18O12， is an important active ingredient in Taraxacum mongolicum， Echinacea purpurea， Cichorium intybus and other natural plants， and it helps plants protect themselves from insects and infection from viruses， bacteria， fungi， and nematodes. Modern pharmacological research suggests that chicoric acid has significant bioactivities such as anti-inflammatory， antioxidant， immune-regulating， antibacterial， antiviral and anti-tumor properties. The first reported bioactivity of chicoric acid is its inhibitory effect on human immunodeficiency virus （HIV）. With the development and application of molecular biology and related technologies， the inhibitory activities of chicoric acid on other viruses as well as its mechanism of action have been frequently reported. Another study indicates that chicoric acid has significant inhibitory effects on different pathogenic bacteria. This paper summarized the research progress on the antiviral and antibacterial effects of chicoric acid through a comprehensive review of relevant literature in China and abroad in the past 20 years. Studies have shown that chicoric acid has significant inhibitory activities against various viruses such as HIV， hepatitis B virus （HBV）， respiratory syncytial virus （RSV）， and herpes simplex virus （HSV）， as well as different pathogenic bacteria such as Staphylococcus aureus， Yersinia enterocolitica and Mycobacterium tuberculosis. This study is expected to provide references for in-depth research on chicoric acid against pathogenic microorganisms and antiviral and antibacterial study of traditional Chinese medicine.
