Clinical Efficacy of Negative Pressure Sealing Drainage Combined with Compound Huangbai Liquid on Diabetic Foot and Effect on Serum Inflammatory Factors
10.13422/j.cnki.syfjx.20222392
- VernacularTitle:负压封闭引流联合复方黄柏液涂剂治疗糖尿病足的临床疗效及对血清炎症因子的影响
- Author:
Xinyu WU
1
;
Nana HAN
2
;
Pengfei ZHANG
1
Author Information
1. The First Clinical Medical College，Shandong University of Traditional Chinese Medicine（TCM），Jinan 250014，China
2. Rizhao Hospital of TCM，Rizhao 276800，China
- Publication Type:Journal Article
- Keywords:
negative pressure sealing drainage;
diabetic foot;
compound Huangbai liquid;
clinical efficacy;
inflammatory factors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(24):153-159
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical efficacy of negative pressure sealing drainage combined with compound Huangbai liquid on diabetic foot and effects on serum inflammatory factors. MethodA total of 168 patients with diabetic foot treated in Rizhao Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were enrolled and randomly divided into a control group （84 cases） and an experimental group （84 cases）. All patients received basic treatment such as blood glucose control and anti-infection. The patients in the control group were treated with negative pressure drainage combined with normal saline，while those in the experimental group were treated with negative pressure drainage combined with compound Huangbai liquid. The ulcer areas，Visual Analogue Scale （VAS） scores，ankle-brachial index （ABI），CT angiography of the lower extremities （diameter of the dorsalis pedis artery，average blood velocity，and blood flow），and serum inflammatory factors［C-reactive protein （CRP），interleukin-6 （IL-6）， and tumor necrosis factor-α （TNF-α）］ of the two group were compared before and after treatment，and the quality of life，satisfaction，and clinical efficacy of patients in the two groups were assessed after treatment. ResultCompared with the conditions before treatment，the two groups showed reduced ulcer areas，VAS scores，mean blood flow rate of dorsal foot artery，CRP，IL-6，and TNF-α levels （P<0.05），increased ABI，dorsum arterial blood flow，and lumen diameter（P<0.05），and improved quality of life （P<0.05）. Compared with the control group after treatment，the experimental group showed superior improvement in the ulcer area，VAS score，ABI，mean blood flow rate of dorsal foot artery，blood flow，and serum inflammatory factors（P<0.05），better quality of life，and higher satisfaction of treatment effect （P<0.05）. Under different treatment protocols，the total clinical effective rate of the experimental group was 92.86%（78/84），higher than 71.43%（60/84） in the control group （χ2=13.070，P<0.05）. ConclusionNegative pressure sealing drainage combined with compound Huangbai liquid for the treatment of diabetic foot can effectively relieve the clinical symptoms in patients，reduce ulcer area and VAS score，improve the blood circulation in dorsalis pedis artery，and decrease the levels of CRP，IL-6，and TNF-α，thereby inhibiting the occurrence of inflammatory reaction.
