Relaxant Effects of Thiopental, Ketamine, and Propofol on Isolated Rat Tracheal smooth Muscle.
10.4097/kjae.2001.41.6.727
- Author:
Sun Chong KIM
1
;
Soon Im KIM
;
In Suk JEON
;
Sang Chul BAI
;
Jeong Seok LEE
;
Sung Yell KIM
Author Information
1. Department of Anesthesiology, College of Medicine, Soonchunhyang University, Seoul, Korea. soonnim@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
Airway: trachea;
tracheal smooth muscle tension;
Anesthetics, intravenous: thiopental;
ketamine;
propofol;
Animal: rat
- MeSH:
Acetylcholine;
Anesthetics, Intravenous;
Animals;
Baths;
Ketamine*;
Muscle, Smooth*;
Propofol*;
Rats*;
Relaxation;
Thiopental*;
Trachea
- From:Korean Journal of Anesthesiology
2001;41(6):727-733
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Intravenous anesthetics may modify airway responsiveness. The author investigated the relaxant effect of thiopental, ketamine, and propofol on isolated rat tracheal smooth muscles. METHODS: The trachea of the rat was dissected and cut into 3-mm rings. The rings were mounted in a water-jacked organ bath filled with Krebs solution aerated with 95% O2 and 5% CO2 at 37degreesC. Thiopental, ketamine, and propofol were given randomly to each ring preconstricted with EC50 of acetylcholine from 10(-6) to 10(-3) M. The relaxation response was the tension during anesthetic equilibration, expressed as a percentage of the tension from EC50 of acetylcholine. RESULTS: Thiopental and propofol (10(-5) to 10(-3) M) relaxed acetylcholine-induced contractions in a dose dependent manner (P < 0.05). Ketamine in doses of 10(-5) and 10(-4) M constricted acetylcholine-induced contractions by 3.2% and 16.5% respectively (P < 0.05). But ketamine in a dose of 10(-3) relaxed acetylcholine-induced contractions by 76.4% (P < 0.05). The relaxation of tracheal smooth muscles was greatest in thiopental, and was least in ketamine (P < 0.05). CONCLUSIONS: All three intravenous anesthetics have an excellent relaxation of tracheal smooth muscles in rats, except in doses of 10(-5) and 10(-4) M of ketamine.
