Molecular mechanism of liver injury in acute pancreatitis
10.3969/j.issn.1001-5256.2022.11.045
- VernacularTitle:急性胰腺炎肝损伤的分子机制
- Author:
Wenqian XU
1
;
Min GUO
2
;
Xiao WANG
2
;
Yaoqi WU
1
;
Jinyuan ZHANG
1
;
Heguo LI
2
Author Information
1. The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, China
2. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Reviews
- Keywords:
Acute Pancreatitis;
Liver Injury;
Cytokines
- From:
Journal of Clinical Hepatology
2022;38(11):2663-2668
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis often progresses rapidly, and if it is not controlled in time, it may lead to multiple organ injury and even death due to organ failure. At present, there is still a high proportion of patients with acute pancreatitis who died due to liver failure. The liver and the pancreas are interrelated physiologically and affect each other pathologically. This article elaborates on the molecular mechanism of liver injury in acute pancreatitis from the six aspects of the physiological relationship between the pancreas and the liver, cytokines, inflammatory response, oxidative stress, microcirculation disturbance, and intestinal flora translocation.
