The role of competitive endogenous RNA in the development of cholangiocarcinoma
10.3969/j.issn.1001-5256.2022.11.044
- VernacularTitle:竞争性内源RNA在胆管细胞癌发生发展中的作用
- Author:
Baolin XU
1
;
Yu CHENG
1
;
Yong WEI
1
Author Information
1. Department of Hepatobiliary, Pancreatic and Splenic Surgery, The Affiliated Yantai Hospital of Binzhou Medical University, Yantai, Shandong 264100, China
- Publication Type:Reviews
- Keywords:
Bile Duct Neoplasms;
RNA;
RNA, Long Noncoding
- From:
Journal of Clinical Hepatology
2022;38(11):2659-2662
- CountryChina
- Language:Chinese
-
Abstract:
Cholangiocarcinoma is a highly malignant tumor with a poor prognosis, limited treatment options, and complicated pathogenesis. Competitive endogenous RNA is a kind of transcripts that can competitively bind miRNA, including long non-coding RNA and circular RNA. Competitive endogenous RNA is known to be involved in a variety of tumors. It can modulate the occurrence and development of cholangiocarcinoma by regulating the biological behavior, cell metabolism, inflammatory process and epithelial-mesenchymal transition of cholangiocarcinoma cells. Here we review recent research progress on the role of long non-coding RNA and circular RNA in cholangiocarcinoma to help better understand the pathogenesis of cholangiocarcinoma.
