Regulation of hepatocyte polarity
10.3969/j.issn.1001-5256.2022.11.043
- VernacularTitle:肝细胞极性调控
- Author:
Yuanpeng MAO
1
;
Hongshan WEI
1
,
2
Author Information
1. Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, China
2. Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Publication Type:Reviews
- Keywords:
Liver Diseases;
Hepatocytes;
Cell Polarity
- From:
Journal of Clinical Hepatology
2022;38(11):2654-2658
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocytes are highly polarized cells, and the establishment and maintenance of hepatocyte polarity are critical for the various functions of hepatocytes. The dynamic stability of hepatocyte polarity is associated with various factors including intercellular junctions, polarity complex proteins, and several signaling pathways. Abnormal hepatocyte function is often observed when polarity gets destroyed, which may eventually lead to various liver diseases. At present, there are still a few studies on the regulation of hepatocyte polarity, and many key factors have not been fully elucidated. This article briefly introduces the recent research advances in the regulation of hepatocyte polarity.
