Research advances in bone marrow mesenchymal stem cells and its exosomes in treatment of end-stage liver disease
10.3969/j.issn.1001-5256.2022.11.041
- VernacularTitle:骨髓间充质干细胞及其外泌体治疗终末期肝病的研究进展
- Author:
Yue LIANG
1
,
2
;
Yonghong HU
1
,
2
;
Wei LIU
1
,
2
;
Yongping MU
1
,
2
;
Jiamei CHEN
1
,
2
;
Ping LIU
1
,
2
,
3
Author Information
1. Institute of Liver Diseases, Shanghai Institute of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai Key Laboratory of Traditional Chinese Medicine, Shanghai 201203, China
3. Shanghai Advanced Base of Chemistry and Biology of Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Reviews
- Keywords:
End-Stage Liver Disease;
Mesenchymal Stem Cells;
Exosomes;
Therapeutics
- From:
Journal of Clinical Hepatology
2022;38(11):2643-2648
- CountryChina
- Language:Chinese
-
Abstract:
End-stage liver disease is the late stage of various acute and chronic liver diseases with high mortality and seriously threatens people's health. Liver transplantation is currently an effective treatment method for this disease, but its clinical application is greatly limited by the factors such as shortage of donors and high costs. In recent years, clinical and basic studies have shown that bone marrow mesenchymal stem cell and its exosomes have good clinical application prospects in the treatment of end-stage liver disease. This article reviews the mechanism of action and clinical application of bone marrow mesenchymal stem cell and its exosomes in the treatment of end-stage liver disease, so as to provide a reference for further research.
