Research advances in traditional Chinese medicine in regulating epithelial-mesenchymal transformation to inhibit hepatocellular carcinoma metastasis
10.3969/j.issn.1001-5256.2022.11.040
- VernacularTitle:中医药调控上皮-间质转化抑制肝癌转移的研究进展
- Author:
Jue WANG
1
;
Chunlei ZHANG
2
;
Kaiyue TANG
1
;
Peiyong ZHENG
1
;
Haiyan SONG
1
Author Information
1. Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
2. Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
- Publication Type:Reviews
- Keywords:
Liver Neoplasms;
Neoplasm Metastasis;
Epithelial-Mesenchymal Transition;
Drugs, Chinese Herbal
- From:
Journal of Clinical Hepatology
2022;38(11):2636-2642
- CountryChina
- Language:Chinese
-
Abstract:
Metastasis is an important factor for the high recurrence and mortality rates of hepatocellular carcinoma (HCC), and epithelial-mesenchymal transition (EMT) is an important mechanism of HCC metastasis. EMT is regulated by the transcription factors such as Snail, Twist, and ZEB which are mediated by a variety of signaling pathways including TGF-β, Wnt/β-catenin, and Notch. Inhibition of EMT-related molecules and signal pathways in HCC is considered as an important approach to inhibit the invasion and metastasis of HCC. Recent studies have shown that a variety of compound traditional Chinese medicine (TCM) formula or their effective constituents can inhibit the invasion and metastasis of HCC by arresting or reversing EMT in HCC. This article reviews the role and mechanism of EMT and recent studies on TCM drugs and their derived natural compounds in inhibiting the invasion and metastasis of HCC by regulating cell EMT, so as to provide a scientific basis for the TCM prevention and treatment of HCC metastasis and new ideas for HCC treatment.
