Function and regulatory mechanism of T lymphocytes in tumor immune microenvironment of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.11.037
- VernacularTitle:肝细胞癌肿瘤免疫微环境中T淋巴细胞的功能与调控机制
- Author:
Mengkui HAN
1
;
Jin LI
2
;
Xiaohua YANG
1
Author Information
1. Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215031, China
2. Department of Clinical Laboratory, the Fifth People's Hospital of Suzhou, Suzhou, Jiangsu 215131, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
T Lymphocyte;
Immune Microenvironment;
Immunotherapy
- From:
Journal of Clinical Hepatology
2022;38(11):2621-2626
- CountryChina
- Language:Chinese
-
Abstract:
As the key immune cells in tumor immune microenvironment, T lymphocytes can affect the proliferation and migration of hepatocellular carcinoma (HCC) cells and control tumor progression through the secretion of cytokines, cytotoxic enzymes (perforin, granzyme B), and other pathways. At the same time, immune cells such as dendritic cells and myeloid-derived suppressor cells in tumor immune microenvironment can regulate the immune function of different T cell subsets through various pathways. This article summarizes the influence of common immune cells in tumor immune microenvironment on the function of T lymphocytes and the mechanism of action of key signaling pathways associated with the functional regulation of T lymphocytes in HCC, so as to provide ideas and clues for developing better therapeutic strategies for HCC.
