Mechanism of NLRP3 inflammasome promoting hepatic stellate cell activation
10.3969/j.issn.1001-5256.2022.11.035
- VernacularTitle:NLRP3炎症小体激活促进肝星状细胞活化的机制
- Author:
Jing PENG
1
;
Wei YUAN
1
;
Sihan YIN
1
;
Kewei SUN
1
Author Information
1. Department of Hepatology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Hepatic Stellate Cells;
NLRP3 Inflammasome;
Inflammatory Microenvironment
- From:
Journal of Clinical Hepatology
2022;38(11):2611-2615
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is the common result of various chronic liver injuries and can progress to liver cirrhosis and even liver cancer, and at present, there is still no effective means to reverse liver fibrosis. The transformation of activated hepatic stellate cells (HSC) in perisinusoidal space into myofibroblasts and the secretion of collagen are a central event in the process of liver fibrosis. NLRP3 inflammasome can be activated by various injury stimuli and mediate inflammatory response and pyroptosis. Recent studies have found that the activation of NLRP3 inflammasome is closely associated with HSC activation. This article introduces the activation of NLRP3 inflammasome in different pathways in HSC under various pathological factors and role of NLRP3 inflammasome in the formation of extracellular inflammatory microenvironment, thereby mediating HSC activation and playing an important role in promoting liver fibrosis.
