Research progress on signal pathways in hepatic fibrosis and targeted regulation mechanisms of active ingredients from traditional Chinese medicine
10.3969/j.issn.1001-5256.2022.11.033
- VernacularTitle:肝纤维化相关信号通路及中药活性成分靶向调节作用机制
- Author:
Wenyan FAN
1
;
Junyu HAO
1
;
Hongxiu CHEN
1
;
Guangwei LIU
2
Author Information
1. The First Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Hepatic Stellate Cells;
Signal Transduction;
Drugs, Chinese Herbal
- From:
Journal of Clinical Hepatology
2022;38(11):2599-2605
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis is a common pathological stage of many chronic liver diseases. Activation of hepatic stellate cells is considered as a key event in the progression of hepatic fibrosis. The pathogenesis of liver fibrosis is modulated by various cytokines involved in several signal pathways, including NF-κB, TGF-β/Smad, Wnt/β-catenin, Hedgehog etc. With the rapid development of modern pharmacology and biotechnology, the underlying molecular mechanism of anti-liver fibrosis of active components from traditional Chinese medicine has been further elucidated. This article summarizes scientific outcomes of signal pathways involved in liver fibrosis and how active components of Chinese herbal medicines exhibit anti-liver fibrosis effects, aiming to provide a potential drug candidate as a treatment for liver fibrosis and to open up a new research field of therapeutics for liver fibrosis.
